{"id":1703,"date":"2022-05-27T05:39:39","date_gmt":"2022-05-27T05:39:39","guid":{"rendered":"https:\/\/www.studioodontoiatricopellegrino.it\/?page_id=1703"},"modified":"2024-03-01T09:49:58","modified_gmt":"2024-03-01T09:49:58","slug":"rigenerazione-tessuto-orale","status":"publish","type":"page","link":"https:\/\/www.studioodontoiatricopellegrino.it\/en_gb\/services\/rigenerazione-tessuto-orale\/","title":{"rendered":"Oral Tissue Regeneration"},"content":{"rendered":"<p><section id=\"bt_bb_section69f0d17969862\"  data-background_image_src=\"'https:\/\/www.studioodontoiatricopellegrino.it\/wp-content\/uploads\/2020\/01\/background-4.jpg'\" class=\"bt_bb_section bt_bb_color_scheme_1 bt_bb_layout_boxed_1200 bt_bb_vertical_align_top btLazyLoadBackground bt_bb_background_image bt_bb_background_overlay_alternate_solid bt_bb_section_show_left_boxed_content\" style=\"background-image:url(&#039;https:\/\/www.studioodontoiatricopellegrino.it\/wp-content\/plugins\/bold-page-builder\/img\/blank.gif&#039;);;background-color:#0e54ae;\" data-bt-override-class=\"null\"><div class=\"bt_bb_port\"><div class=\"bt_bb_cell\"><div class=\"bt_bb_cell_inner\"><div class=\"bt_bb_row  bt_bb_column_gap_25\" style=\"; --column-gap:25px;\" data-bt-override-class=\"{}\"><div class=\"bt_bb_row_holder\" ><div  class=\"bt_bb_column col-xl-6 bt_bb_align_left bt_bb_vertical_align_middle bt_bb_animation_fade_in animate bt_bb_padding_double\"  data-width=\"6\" data-bt-override-class=\"{}\"><div class=\"bt_bb_column_content\"><div class=\"bt_bb_separator bt_bb_border_style_none bt_bb_top_spacing_small bt_bb_bottom_spacing_normal\" data-bt-override-class=\"null\"><\/div><header class=\"bt_bb_headline bt_bb_font_weight_bolder bt_bb_dash_none bt_bb_size_huge bt_bb_align_inherit bt_bb_dash_type_none\" data-bt-override-class=\"{&quot;bt_bb_size_&quot;:{&quot;current_class&quot;:&quot;bt_bb_size_huge&quot;,&quot;def&quot;:&quot;huge&quot;,&quot;xl&quot;:&quot;huge&quot;},&quot;bt_bb_align_&quot;:{&quot;current_class&quot;:&quot;bt_bb_align_inherit&quot;,&quot;def&quot;:&quot;inherit&quot;,&quot;xl&quot;:&quot;inherit&quot;}}\"><h1 class=\"bt_bb_headline_tag\"><span class=\"bt_bb_headline_content\"><span>Oral Tissue Regeneration<\/span><\/span><\/h1><\/header><div class=\"bt_bb_separator bt_bb_border_style_none bt_bb_bottom_spacing_small\" data-bt-override-class=\"null\"><\/div><div  class=\"bt_bb_text\" ><\/p>\n<p><strong>Questo approccio proposto nel nostro Studio esalta salute e qualit\u00e0 del parodonto.<\/strong><\/p>\n<p><strong>RECUPERARE o MANTENERE la SALUTE richiede un percorso che \u201ccuri\u201d dall\u2019interno<\/strong><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p>\n<\/div><div class=\"bt_bb_separator bt_bb_border_style_solid bt_bb_top_spacing_small bt_bb_bottom_spacing_small\" data-bt-override-class=\"null\"><\/div><div class=\"bt_bb_column_highlight\"><\/div><\/div><\/div><div  class=\"bt_bb_column col-xl-6 bt_bb_align_left bt_bb_vertical_align_middle bt_bb_animation_fade_in animate bt_bb_padding_normal btLazyLoadBackground bt_bb_column_background_image bt_bb_mobile_align_to_both_edges\" style=\"padding: 0;background-image:url(&#039;https:\/\/www.studioodontoiatricopellegrino.it\/wp-content\/plugins\/bold-page-builder\/img\/blank.gif&#039;);\" data-background_image_src='https:\/\/www.studioodontoiatricopellegrino.it\/wp-content\/uploads\/2020\/02\/teeth-after.jpg' data-width=\"6\" data-bt-override-class=\"{&quot;bt_bb_align_&quot;:{&quot;current_class&quot;:&quot;bt_bb_align_left&quot;,&quot;def&quot;:&quot;left&quot;,&quot;xl&quot;:&quot;left&quot;},&quot;bt_bb_padding_&quot;:{&quot;current_class&quot;:&quot;bt_bb_padding_normal&quot;,&quot;def&quot;:&quot;normal&quot;,&quot;xl&quot;:&quot;normal&quot;}}\"><div class=\"bt_bb_column_content\"><div class=\"bt_bb_separator bt_bb_border_style_none bt_bb_top_spacing_extra_large bt_bb_bottom_spacing_extra_large\" data-bt-override-class=\"null\"><\/div><div class=\"bt_bb_separator bt_bb_border_style_none bt_bb_top_spacing_small bt_bb_bottom_spacing_small\" data-bt-override-class=\"{&quot;bt_bb_top_spacing_&quot;:{&quot;current_class&quot;:&quot;bt_bb_top_spacing_small&quot;,&quot;def&quot;:&quot;small&quot;,&quot;xl&quot;:&quot;small&quot;},&quot;bt_bb_bottom_spacing_&quot;:{&quot;current_class&quot;:&quot;bt_bb_bottom_spacing_small&quot;,&quot;def&quot;:&quot;small&quot;,&quot;xl&quot;:&quot;small&quot;}}\"><\/div><div class=\"bt_bb_column_highlight\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section id=\"bt_bb_section69f0d1796a4dc\" data-parallax=\"0.7\" data-parallax-offset=\"400\" data-background_image_src=\"'https:\/\/www.studioodontoiatricopellegrino.it\/wp-content\/uploads\/2020\/02\/background-3.png'\" class=\"bt_bb_section bt_bb_layout_boxed_1200 bt_bb_vertical_align_top bt_bb_parallax btLazyLoadBackground bt_bb_background_image\" style=\"background-image:url(&#039;https:\/\/www.studioodontoiatricopellegrino.it\/wp-content\/plugins\/bold-page-builder\/img\/blank.gif&#039;);z-index: 2;background-size:100% auto;\" data-bt-override-class=\"null\"><div class=\"bt_bb_port\"><div class=\"bt_bb_cell\"><div class=\"bt_bb_cell_inner\"><div class=\"bt_bb_row  bt_bb_column_gap_25\" style=\"margin-top: -3em;; --column-gap:25px;\" data-bt-override-class=\"{}\"><div class=\"bt_bb_row_holder\" ><div  class=\"bt_bb_column col-xl-8 bt_bb_align_left bt_bb_vertical_align_top bt_bb_animation_fade_in animate bt_bb_padding_normal\"  data-width=\"8\" data-bt-override-class=\"{}\"><div class=\"bt_bb_column_content\"><div class=\"bt_bb_separator bt_bb_border_style_none bt_bb_top_spacing_normal bt_bb_bottom_spacing_large\" data-bt-override-class=\"null\"><\/div><header class=\"bt_bb_headline bt_bb_font_weight_bolder bt_bb_color_scheme_17 bt_bb_dash_none bt_bb_size_extralarge bt_bb_align_inherit bt_bb_dash_type_none\" style=\"; --primary-color:#0e54ae; --secondary-color:#08a9c9;\" data-bt-override-class=\"{&quot;bt_bb_size_&quot;:{&quot;current_class&quot;:&quot;bt_bb_size_extralarge&quot;,&quot;def&quot;:&quot;extralarge&quot;,&quot;xl&quot;:&quot;extralarge&quot;},&quot;bt_bb_align_&quot;:{&quot;current_class&quot;:&quot;bt_bb_align_inherit&quot;,&quot;def&quot;:&quot;inherit&quot;,&quot;xl&quot;:&quot;inherit&quot;}}\"><h2 class=\"bt_bb_headline_tag\"><span class=\"bt_bb_headline_content\"><span><small>How oral tissue regeneration occurs <\/small><br \/><br \/>\nDiscover the new frontier of regeneration<br \/><br \/>\nUNA VISIONE SISTEMICA DELLA MALATTIA PARODONTALE<\/span><\/span><\/h2><\/header><div class=\"bt_bb_separator bt_bb_border_style_none bt_bb_bottom_spacing_small\" data-bt-override-class=\"null\"><\/div><div  class=\"bt_bb_text\" ><\/p>\n<p><strong>At the root of the problem<\/strong><\/p>\n<p>This type of approach involves the\u00a0 <strong>reactivation of the dynamics of periodontal tissue restoration<\/strong>. L\u2019obiettivo sar\u00e0, quindi, quello di agire\u00a0 alla radice del problema concentrandosi primariamente sulle <strong>causes<\/strong> etiological of the problem itself.<\/p>\n<p><strong>Bio-detox and Bio-stimulation<\/strong><\/p>\n<p>Il percorso riabilitativo si sviluppa in due step:\u00a0la fase di <a href=\"https:\/\/aesthetics.guna.com\/multi-systems-aesthetic-medicine\/\"><em>Bio-detox<\/em>\u00a0e\u00a0la fase di <em>Bio-stimulation<\/em><\/a>. \u00a0La prima fase \u00e8 caratterizzata dall\u2019assunzione di drenanti per via orale, mentre nella seconda fase si utilizzano sostanze per uso topico.<\/p>\n<p>As with all good things, this process also takes some time, but the results are usually very promising.<\/p>\n<p>Agendo sulla vitalit\u00e0 cellulare e ripristinando gli equilibri fisiologici che la sostengono, questo approccio rallenta e inverte il fenomeno dell\u2019<em>aging <\/em>\u00a0inteso come\u00a0 manifestazione di uno squilibrio pi\u00f9 ampio dei sistemi che regolano le funzioni principali dell\u2019organismo.<\/p>\n<p>There are 2 distinct therapeutic moments (<em>steps<\/em>\u00a01 and\u00a0<em>steps<\/em>\u00a02) which can be applied in succession or in parallel, based on the personalized treatment strategy on each patient.<\/p>\n<p><em>STEP 1<\/em>\u00a0\u2013\u00a0<strong>BIO-DETOX<\/strong>: provides a systemic oral therapy, aimed at draining toxins from the extracellular matrix.<\/p>\n<p><em>STEP 2<\/em>\u00a0\u2013\u00a0<strong>BIO-STIMULATION<\/strong>: consists of a local therapy, aimed at the bio-stimulation of cell turnover processes. It exponentially amplifies its effectiveness, thanks to the detoxification of the periodontal tissue that took place during the <em>steps<\/em>\u00a0of bio-detox.<\/p>\n<p>Both\u00a0<em>steps<\/em> prevedono l\u2019impiego di soluzioni che agiscono a pi\u00f9 livelli per effetto di farmaci multi-componenti di origine naturale e molecole biotech a basso dosaggio, capaci di modulare finemente i meccanismi fisiologici che regolano l\u2019invecchiamento dei tessuti, garantendo allo stesso tempo elevata tollerabilit\u00e0.<\/p>\n<p>THE SYSTEMIC AGING PROCESS<\/p>\n<p>Studi clinici dimostrano che, quando i parametri dell\u2019equilibrio omeostatico vengono alterati, si innesca da una parte un processo infiammatorio, dall\u2019altra un declino istologico ed entrambi concorrono in modo importante al processo di invecchiamento dei tessuti. Un \u201ckiller\u201d silenzioso \u00e8 all\u2019origine di molti dei meccanismi che sottendono i processi di <em>aging\u00a0<\/em>cellular and tissue: the\u00a0<em>Low Grade Chronic Infiammation<\/em>. Silente e asintomatica, essa conduce progressivamente alle alterazioni istologiche della matrice extracellulare, compromettendo il normale flusso di nutrienti e molecole segnale dai vasi alle cellule. Il risultato sar\u00e0 una perdita di vitalit\u00e0 dei tessuti.<\/p>\n<p>Fino all\u2019et\u00e0 di 25\/30 anni, la capacit\u00e0 di recuperare autonomamente l\u2019equilibrio omeostatico \u00e8 elevata, ma successivamente diventa sempre pi\u00f9 debole fino a deteriorarsi dopo i 50 anni. \u00c8 possibile, agendo in prevenzione o in ripristino, mantenere il pi\u00f9 a lungo possibile tale capacit\u00e0 o invertire il suo trend.<\/p>\n<p>\n<\/div><div class=\"bt_bb_separator bt_bb_border_style_none bt_bb_top_spacing_normal bt_bb_bottom_spacing_normal\" data-bt-override-class=\"{&quot;bt_bb_top_spacing_&quot;:{&quot;current_class&quot;:&quot;bt_bb_top_spacing_normal&quot;,&quot;def&quot;:&quot;normal&quot;,&quot;xl&quot;:&quot;normal&quot;},&quot;bt_bb_bottom_spacing_&quot;:{&quot;current_class&quot;:&quot;bt_bb_bottom_spacing_normal&quot;,&quot;def&quot;:&quot;normal&quot;,&quot;xl&quot;:&quot;normal&quot;}}\"><\/div><header class=\"bt_bb_headline bt_bb_font_weight_bolder bt_bb_color_scheme_17 bt_bb_dash_none bt_bb_size_extralarge bt_bb_align_inherit bt_bb_dash_type_none\" style=\"; --primary-color:#0e54ae; --secondary-color:#08a9c9;\" data-bt-override-class=\"{&quot;bt_bb_size_&quot;:{&quot;current_class&quot;:&quot;bt_bb_size_extralarge&quot;,&quot;def&quot;:&quot;extralarge&quot;,&quot;xl&quot;:&quot;extralarge&quot;},&quot;bt_bb_align_&quot;:{&quot;current_class&quot;:&quot;bt_bb_align_inherit&quot;,&quot;def&quot;:&quot;inherit&quot;,&quot;xl&quot;:&quot;inherit&quot;}}\"><h2 class=\"bt_bb_headline_tag\"><span class=\"bt_bb_headline_content\"><span>Biotox and Biostimulation<br \/><br \/>\nStep1 and Step 2<\/span><\/span><\/h2><\/header><div class=\"bt_bb_separator bt_bb_border_style_none bt_bb_top_spacing_extra_small bt_bb_bottom_spacing_small\" data-bt-override-class=\"null\"><\/div><div  class=\"bt_bb_text\" ><\/p>\n<p>STEP 1: BIO-DETOX<\/p>\n<p>Il\u00a0<strong>bio-detox<\/strong> riduce i fenomeni infiammatori cronici, una delle principali cause dell\u2019invecchiamento, attraverso un\u2019azione di drenaggio della matrice extracellulare, da potenziare, quando necessario, anche con il drenaggio linfatico ed emuntoriale.<\/p>\n<p>The bio-detox is done by drugs\u00a0<em>multi-component<\/em>\u00a0and\u00a0<em>multi-target<\/em>, based on selected substances of natural and biological origin. The solution par excellence of\u00a0<em>steps<\/em>\u00a0of bio-detox performs 4 actions at the same time: <strong>Anti-inflammatory, Antioxidant, Draining, Detoxifying.<\/strong><\/p>\n<p>This\u00a0<em>steps<\/em>\u00a0pu\u00f2 essere ulteriormente potenziato da farmaci biotech a base di molecole segnale\u00a0<em>low dose<\/em>, come le citochine, in grado di contrastare la sovra espressione\u00a0 dei m<em>arker<\/em>\u00a0inflammatory, and growth factors, able to stimulate tissue trophism.<\/p>\n<p>STEP 2: BIO-STIMULATION<\/p>\n<p>La bio-stimolazione \u00e8 un\u2019azione a pi\u00f9 livelli, utile a contrastare il declino istologico. Le cellule del derma vengono stimolate al fine di riattivare i loro processi biologici naturali e favorire il loro\u00a0<em>turnover<\/em>.<\/p>\n<p>La bio-stimolazione avviene grazie all\u2019azione sinergica di farmaci\u00a0<em>multi-component<\/em>\u00a0and\u00a0<em>multi-target<\/em>, based on low-dose active ingredients, e\u00a0<em>medical device<\/em>\u00a0a base di collagene, in grado di modulare finemente il meccanismo fisiopatologico che provoca l\u2019invecchiamento.<\/p>\n<p>BIBLIOGRAPHICAL REFERENCES<\/p>\n<ol>\n<li>Barabasi, A. L., Oltvai, Z. N. Z. N. &amp; Barab\u00e1si, A. L. Network biology: understanding the cell\u2019s functional organization. Nat. Rev. Genet. 5, 101\u2013113 (2004).<\/li>\n<li>Barygina V, Becatti M, Lotti T, Moretti S, Taddei N, et al. Treatment with I.ow-dose cytokines reduces oxidative-mediated injury in perilesional keratinocytes from vitiligo skin. J Dermatol Sci. 2015;79(2): 163-70.<\/li>\n<li>Barygina V, Becatti M, Lotti T, Taddei N, Fiorillo C. Low dose cytokines reduce oxidative stress in primary lesional fibroblasts obtained from psoriatic patients. J Dermatol Sci. 2016;83(3):242-4.<\/li>\n<li>Benvenuto M, Mattera R, Miele MT, Giganti MG, Tresoldi I, Albonici L, Manzari V, et al. E\u00a2ects of a natural multi-component compound formulation on the growth, morphology and extracellular matrix production of human adult dermal fibroblasts. Exp Ther Med. 2019;18(4): 2639-47.<\/li>\n<li>De Bellis M. Treatment of wrinkles and skin relaxation with intradermal injections of a complex homeopathic drug (Made). Results of a multicenter study of 681 patients. Biological Medicine 2\/2004<\/li>\n<li>Del Prete M., Lozzi A. Low Dose Medicine and Inflammation. Low Dosage Pharmacology in the treatment of acute, chronic and autoimmune inflammatory diseases. IPSA Editore 2017<\/li>\n<li>Fioranelli M. and Roccia M.G. (2014). Twentyfive years of studies and trials for the therapeutic application of IL-10 immunomodulating properties. From high doses administration to low dose medicine new paradigm. J. Integr. Cardiol., 1(1): 2-6. 10.15761\/JIC.1000102<\/li>\n<li>Goldman AW, Burmeister Y, Cesnulevicius K, et al. Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, infiammation, and systems biology with the patient\u2019s autoregulatory capacity? Front Physiol. 2015;6:225.<\/li>\n<li>Lieleg O, Baumg\u00e4rtel RM, Bausch AR. Selective filtering of particles by the extracellular matrix: an electrostatic bandpass. Biophys J. 2009;97(6):1569- 1577. 10.15761\/JIC.1000102<\/li>\n<li>Perra A. et al. L\u2019universo della \u201cmatrice extracellulare\u201d. Rapporti tra Galium -Heel\u00ae, plasticit\u00e0 e rigidit\u00e0 del microambiente cellulare. Advanced Therapies n\u00b0 15 2018<\/li>\n<li>Randelli F, Menon A, Giai Via A, Mazzoleni MG, Sciancalepore F, Brioschi M, Gagliano N. E\u00a2ect of a Collagen-Based Compound on Morpho-Functional Properties of Cultured Human Tenocytes. Cells. 2018;7(12).<\/li>\n<li>Rolman o. et al. Platelet Derived Growth Factor (PDGF) Responsive Epidermis Formed from Human Keratinocytes Transduced with the PDGF\u03b2 Receptor Gene. Journal of Investigative Dermatology Volume 120, Issue 5, May 2003, Pages 742-749<\/li>\n<li>Yalcinkaya E, Celik M, Bugan B. Extracellular matrix turnover: a balance between MMPs and their inhibitors. 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href=\"https:\/\/www.studioodontoiatricopellegrino.it\/en_gb\/services\/ortodonzia\/\">Orthodontics<\/a><\/li>\n<\/ul><\/div><\/div><div class=\"bt_bb_separator bt_bb_border_style_none bt_bb_bottom_spacing_normal\" data-bt-override-class=\"null\"><\/div><div class=\"bt_bb_column_inner_highlight\"><\/div><\/div><\/div><\/div><\/div><div class=\"bt_bb_separator bt_bb_border_style_none bt_bb_bottom_spacing_normal\" data-bt-override-class=\"null\"><\/div><div class=\"bt_bb_column_highlight\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section id=\"bt_bb_section69f0d179705ac\"  class=\"bt_bb_section bt_bb_layout_boxed_1200\"  data-bt-override-class=\"null\"><div class=\"bt_bb_port\"><div class=\"bt_bb_cell\"><div class=\"bt_bb_cell_inner\"><div class=\"bt_bb_row\"  data-bt-override-class=\"{}\"><div class=\"bt_bb_row_holder\" ><div  class=\"bt_bb_column col-xl-12 col-xs-12 col-sm-12 col-md-12 col-lg-12 bt_bb_align_left bt_bb_vertical_align_top bt_bb_padding_normal\"  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Continually reintermediate integrated processes through technically sound intellectual capital. Holistically foster superior methodologies without market-driven best practices.<\/p>","protected":false},"author":1,"featured_media":0,"parent":147,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"two_page_speed":[]},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.studioodontoiatricopellegrino.it\/en_gb\/wp-json\/wp\/v2\/pages\/1703"}],"collection":[{"href":"https:\/\/www.studioodontoiatricopellegrino.it\/en_gb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.studioodontoiatricopellegrino.it\/en_gb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.studioodontoiatricopellegrino.it\/en_gb\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.studioodontoiatricopellegrino.it\/en_gb\/wp-json\/wp\/v2\/comments?post=1703"}],"version-history":[{"count":11,"href":"https:\/\/www.studioodontoiatricopellegrino.it\/en_gb\/wp-json\/wp\/v2\/pages\/1703\/revisions"}],"predecessor-version":[{"id":2423,"href":"https:\/\/www.studioodontoiatricopellegrino.it\/en_gb\/wp-json\/wp\/v2\/pages\/1703\/revisions\/2423"}],"up":[{"embeddable":true,"href":"https:\/\/www.studioodontoiatricopellegrino.it\/en_gb\/wp-json\/wp\/v2\/pages\/147"}],"wp:attachment":[{"href":"https:\/\/www.studioodontoiatricopellegrino.it\/en_gb\/wp-json\/wp\/v2\/media?parent=1703"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}